Team 4
Biology of Innate T cells & Lung immunity
Team leader : Christophe PAGET
The “Biology of Innate T cells & Lung immunity” Lab conducts fundamental researches in the field of innate T (Tinn) cell immunobiology with a peculiar focus on lung immunity including infection and auto-immunity. Our team is organised around three complementary and interconnected axes.
Our expertise includes advance knowledge in mouse and human immunology including innate T cell and Fc receptor biology, and the understanding of lung inflammation from autoimmune and infectious origins. This are valued by applying a translational research approach combining relevant experimental models and clinical studies.Our team creates synergies by bringing together fulltime researcher, assistant professors and MD-PhD from different fields (fundamental immunology, internal medicine, intensive care and biological immunology).
Specifically, we investigate the interplay of key molecular and cellular effectors in response to respiratory infections caused by viruses, bacteria, and fungi.
Our goal is to develop innovative immune-intervention and antimicrobial strategies.
Specifically, we investigate the interplay of key molecular and cellular effectors in response to respiratory infections caused by viruses, bacteria, and fungi.
Our goal is to develop innovative immune-intervention and antimicrobial strategies.
Our axis
Our team is organised around three complementary and interconnected axes
Axis 1
Understanding the factors that control Tinn cell development and homeostasis
Axis 2
Deciphering the activation mechanisms and functions of Tinn cells during infection and auto-immunity
Axis 3
Bringing the grounds for future Tinn cell-based therapies in lung diseases
Members
Team leaders
Christophe PAGET
Thomas BARANEK
Specific expertises
Mouse model
Innate T cell biology
Clinical studies
Flow cytometry
Antibody receptors
Transcriptomics
Cell culture
Key events
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6 grants from ANR (ANRJCJC 2019, ANR RA-COVID 2020, ANR Résilience 2021, ANR PRC 2021, ANR PRC 2022, ANR PRC 2023) obtained over the last 5 years including 3 as coordinator.
Organisation of congress: Annual AIS LabEx MabImprove (from 2013), Annual French Innate T cell symposium (from 2021), Annual SFI meeting 2023 (Strasbourg), European Congress of Immunology (Dublin, 2024).
Head and Steering committee of the Labex « MabImprove ».
Steering committee of the « Société Française d’Immunologie ».
Creation and steering committee of the GDR Innate T cells.
62 original publications over the last 5 years including NEJM, JAMA, Cell, Nat. Immunol., PNAS, JEM…
Coordination of 4 clinical studies dedicated to the study of innate T cells biology in various pathological settings.
Fundings & partnerships
Fundings
Scientific environment
Partners
France
Canada
Austria
Switzerland
Sweden
Ireland
UK
Australia
Germany
USA
