Mike Pasteur, Guillaume Arsouze, Guy Ilango,Déborah Le Pennec, Dimitri Kulker,Anaïs Heyraud, Jean-Philippe Cottier, Charles Aussedat, Nathalie Heuzé-Vourc’h, Virginie Hervé, Sandrine Le Guellec Characterization of anatomical variations of the nasal cavity in a subset of European patients and their impact on intranasal drug delivery. Int J Pharm. 2024 Oct 26;667 (Pt A):124851. doi:10.1016/j.ijpharm.2024.124851. Epub ahead of print. PMID: 39490788.

Creusat F, Jouan Y, Gonzalez L, Barsac E, Ilango G, Lemoine R, Soulard D, Hankard A, Boisseau C, Guillon A, Lin Q, de Amat Herbozo C, Sencio V, Winter N, Sizaret D, Trottein F, Si-Tahar M, Briard B, Mallevaey T, Faveeuw C, Baranek T, Paget C. IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections. Sci Adv. 2024 Oct 11;10(41):eadn3257. doi: 10.1126/sciadv.adn3257. Epub 2024 Oct 11.PMID: 39392875

Domain R, Seren S, Jerke U, Makridakis M, Chen KJ, Zoidakis J, Rhimi M, Zhang X, Bonvent T, Croix C, Gonzalez L, Li D, Basso J, Paget C, Viaud-Massuard MC, Lalmanach G, Shi GP, Aghdassi A, Vlahou A, McDonald PP, Couillin I, Williams R, Kettritz R, Korkmaz B (2024). Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases). Biochem Pharmacol. 2024 Nov;229:116114. doi: 10.1016/j.bcp.2024.116114. Epub 2024 Sep 16.PMID: 39455238

Doz-Deblauwe E, Bounab B, Carreras F, Fahel JS, Oliveira SC, Lamkanfi M, Le Vern Y, Germon P, Pichon J, Kempf F, Paget C, Remot A, Winter N. Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1. Life Sci Alliance. 2024 May 21;7(7):e202402623. doi: 10.26508/lsa.202402623. Print 2024 Jul.PMID: 38803236

Guillon A, Jouan Y, Kassa-Sombo A, Paget C, Dequin PF. Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS. Crit Care. 2024 Mar 28;28(1):101. doi: 10.1186/s13054-024-04887-2.PMID: 38549157

Chesnay A, Gonzalez L, Parent C, Desoubeaux G, Baranek. Description of a Murine Model of Pneumocystis Pneumonia. T.Mycopathologia. 2024 May 6;189(3):42. doi: 10.1007/s11046-024-00846-1.PMID: 38709375

Boulard P, Azzopardi N, Levard R, Cornec JM, Lamamy J, Prieur B, Demattei MV, Watier H, Gatault P, Gouilleux-Gruart V. Albumin influences leucocyte FcRn expression in the early days of kidney transplantation. Clin Exp Immunol. 2024 May 16;216(3):307-317. doi: 10.1093/cei/uxae011.PMID: 38353127

Stiel L, Gaudet A, Thietart S, Vallet H, Bastard P, Voiriot G, Oualha M, Sarton B, Kallel H, Brechot N, Kreitmann L, Benghanem S, Joffre J, Jouan Y. Innate immune response in acute critical illness: a narrative review. la Commission de Recherche Translationnelle de la Société de Réanimation en Langue Française.Ann Intensive Care. 2024 Sep 4;14(1):137. doi: 10.1186/s13613-024-01355-6.PMID: 39227416

Blin T, Parent C, Pichon G, Guillon A, Jouan Y, Allouchi H, Aubrey N, Boursin F, Domain R, Korkmaz B, Sécher T, Heuzé-Vourc’h N. The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies. Eur J Pharm Biopharm. 2024 Feb;195:114163. doi: 10.1016/j.ejpb.2023.12.003. Epub 2023 Dec 10.PMID: 38086491

Richter, F., Paget, C., & Apetoh, L. (2023). STING-driven activation of T cells : Relevance for the adoptive cell therapy of cancer. Cell Stress, 7(11), 95‑104. https://doi.org/10.15698/cst2023.11.291

Giret, C., Dos Santos, Y., Blasco, H., Paget, C., Gonzalez, L., Tressel, N., Dieu, M., Bigot, A., Gissot, V., Audemard-Verger, A., & Maillot, F. (2023). No evidence for systemic low-grade inflammation in adult patients with early-treated phenylketonuria : The INGRAPH study. JIMD Reports, 64(6), 446‑452. https://doi.org/10.1002/jmd2.12366

Pitiot A, Ferreira M, Parent C, Boisseau C, Cortes M, Bouvart L, Paget C, Heuzé-Vourc’h N, Sécher T. Mucosal administration of anti-bacterial antibodies provide long-term cross-protection against Pseudomonas aeruginosa respiratory infection. Mucosal Immunol. 2023 Mar 28:S1933-0219(23)00021-1. doi: 10.1016/j.mucimm.2023.03.005.

Alarcan, H., Berthet, M., Suire, L., Colas, C., Gonzalez, L., Paget, C., Benz-de Bretagne, I., Piver, E., Vourc’h, P., Andres, C., Corcia, P., & Blasco, H. (2022). Inflammatory mediators, lipoproteins and apolipoproteins in early diagnosis of amyotrophic lateral sclerosis. SLAS Technology, 27(5), 327‑334. https://doi.org/10.1016/j.slast.2022.07.003

Santoni, K., Pericat, D., Gorse, L., Buyck, J., Pinilla, M., Prouvensier, L., Bagayoko, S., Hessel, A., Leon-Icaza, S. A., Bellard, E., Mazères, S., Doz-Deblauwe, E., Winter, N., Paget, C., Girard, J.-P., Pham, C. T. N., Cougoule, C., Poincloux, R., Lamkanfi, M., … Planès, R. (2022). Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa. PLoS Pathogens, 18(7), e1010305. https://doi.org/10.1371/journal.ppat.1010305

Baranek, T., de Amat Herbozo, C., Mallevaey, T., & Paget, C. (2022). Deconstructing iNKT cell development at single-cell resolution. Trends in Immunology, 43(7), 503‑512. https://doi.org/10.1016/j.it.2022.04.012

Guillon A, Brea-Diakite D, Cezard A, Wacquiez A, Baranek T, Bourgeais J, Picou F, Vasseur V, Meyer L, Chevalier C, Auvet A, Carballido JM, Nadal Desbarats L, Dingli F, Turtoi A, Le Gouellec A, Fauvelle F, Donchet A, Crépin T, Hiemstra PS, Paget C, Loew D, Herault O, Naffakh N, Le Goffic R, Si-Tahar M. Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. EMBO J. 2022 Jun 14;41(12):e108306. doi: 10.15252/embj.2021108306. Epub 2022 May 4. PMID: 35506364; PMCID: PMC9194747.

Paget, C., Doz-Deblauwe, E., Winter, N., & Briard, B. (2022). Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils : Relevance in Inflammatory and Infectious Diseases. Cells, 11(7), 1188. https://doi.org/10.3390/cells11071188

Chesnay, A., Paget, C., Heuzé-Vourc’h, N., Baranek, T., & Desoubeaux, G. (2022). Pneumocystis Pneumonia : Pitfalls and Hindrances to Establishing a Reliable Animal Model. Journal of Fungi (Basel, Switzerland), 8(2), 129. https://doi.org/10.3390/jof8020129

Bruchard, M., Geindreau, M., Perrichet, A., Truntzer, C., Ballot, E., Boidot, R., Racoeur, C., Barsac, E., Chalmin, F., Hibos, C., Baranek, T., Paget, C., Ryffel, B., Rébé, C., Paul, C., Végran, F., & Ghiringhelli, F. (2022). Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses. Nature Immunology, 23(2), 262‑274.

Flament H, Rouland M, Beaudoin L, Toubal A, Bertrand L, Lebourgeois S, Rousseau C, Soulard P, Gouda Z, Cagninacci L, Monteiro AC, Hurtado-Nedelec M, Luce S, Bailly K, Andrieu M, Saintpierre B, Letourneur F, Jouan Y, Si-Tahar M, Baranek T, Paget C, Boitard C, Vallet-Pichard A, Gautier JF, Ajzenberg N, Terrier B, Pène F, Ghosn J, Lescure X, Yazdanpanah Y, Visseaux B, Descamps D, Timsit JF, Monteiro RC, Lehuen A. Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity. Nat Immunol. 2021 Mar;22(3):322-335. doi: 10.1038/s41590-021-00870-z. Epub 2021 Feb 2. PMID: 33531712.

Jouan Y, Baranek T, Si-Tahar M, Paget C, Guillon A. Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS. Crit Care. 2021 Mar 24;25(1):120. doi: 10.1186/s13054-021-03513-9. PMID: 33761985; PMCID: PMC7988241.

Barsac, E., de Amat Herbozo, C., Gonzalez, L., Baranek, T., Mallevaey, T., & Paget, C. (2021). Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors. Cancers, 13(14), Article 14. https://doi.org/10.3390/cancers13143578

Seren S, Derian L, Keleş I, Guillon A, Lesner A, Gonzalez L, Baranek T, Si-Tahar M, Marchand-Adam S, Jenne DE, Paget C, Jouan Y, Korkmaz B. Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia. Eur Respir J. 2021 Apr 29;57(4):2003755. doi: 10.1183/13993003.03755-2020. PMID: 33419887; PMCID: PMC8082325.

Paget C, Trottein F. COVID-19 and flu: conserved or specific immune signature? Cell Mol Immunol. 2021 Feb;18(2):245-246. doi: 10.1038/s41423-020-00595-3. Epub 2021 Jan 11. Erratum in: Cell Mol Immunol. 2022 Dec;19(12):1439. doi: 10.1038/s41423-022-00914-w. PMID: 33432063; PMCID: PMC7797702.

Baranek T, Lebrigand K, de Amat Herbozo C, Gonzalez L, Bogard G, Dietrich C, Magnone V, Boisseau C, Jouan Y, Trottein F, Si-Tahar M, Leite-de-Moraes M, Mallevaey T, Paget C. High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision. Cell Rep. 2020 Sep 8;32(10):108116. doi: 10.1016/j.celrep.2020.108116. PMID: 32905761.

Jouan Y, Guillon A, Gonzalez L, Perez Y, Boisseau C, Ehrmann S, Ferreira M, Daix T, Jeannet R, François B, Dequin PF, Si-Tahar M, Baranek T, Paget C. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. J Exp Med. 2020 Dec 7;217(12):e20200872. doi: 10.1084/jem.20200872. PMID: 32886755; PMCID: PMC7472174.

Hassane M, Jouan Y, Creusat F, Soulard D, Boisseau C, Gonzalez L, Patin EC, Heuzé-Vourc’h N, Sirard JC, Faveeuw C, Trottein F, Si-Tahar M, Baranek T, Paget C. Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response. Mucosal Immunol. 2020 Jan;13(1):128-139. doi: 10.1038/s41385-019-0212-y. Epub 2019 Oct 18. PMID: 31628425.

Lantier L, Poupée-Beaugé A, di Tommaso A, Ducournau C, Epardaud M, Lakhrif Z, Germon S, Debierre-Grockiego F, Mévélec MN, Battistoni A, Coënon L, Deluce-Kakwata-Nkor N, Velge-Roussel F, Beauvillain C, Baranek T, Lee GS, Kervarrec T, Touzé A, Moiré N, Dimier-Poisson I. Neospora caninum: a new class of biopharmaceuticals in the therapeutic arsenal against cancer. J Immunother Cancer. 2020 Nov;8(2):e001242. doi: 10.1136/jitc-2020-001242. PMID: 33257408; PMCID: PMC7705568.

Lau I, de Amat Herbozo C, Kuypers M, Lin Q, Paget C, Mallevaey T. Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice. Immunohorizons. 2020 Dec 15;4(12):797-808. doi: 10.4049/immunohorizons.2000100. PMID: 33323387.

Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F. TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells. PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169.

Paget C, Trottein F. Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells. Front Immunol. 2019 Mar 1;10:336. doi: 10.3389/fimmu.2019.00336. eCollection 2019. Review.

Trottein F, Paget C. Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections. Front Immunol. 2018 Aug 2;9:1750. doi: 10.3389/fimmu.2018.01750. eCollection 2018. Review.

Jouan Y, Patin EC, Hassane M, Si-Tahar M, Baranek T, Paget C. Thymic Program Directing the Functional Development of γδT17 Cells. Front Immunol. 2018 May 8;9:981. doi: 10.3389/fimmu.2018.00981. eCollection 2018. Review.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH. Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis. Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

Patin EC, Soulard D, Fleury S, Hassane M, Dombrowicz D, Faveeuw C, Trottein F, Paget C. Type I IFN receptor signalling controls IL-7-dependent accumulation and activity of protumoral IL-17A-producing γδT cells in breast cancer. Cancer Res. 2017 Oct 25. pii: canres.1416.2017. doi: 10.1158/0008-5472.CAN-17-1416. [Epub ahead of print]

Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C. Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038/mi.2016.113.

Le Gars M, Haustant M, Klezovich-Benard M, Paget C, Trottein F, Goossens PL, Tournier JN. iNKT cells: potential therapeutic targets to fight anthrax. Med Sci (Paris). 2017 May;33(5):488-490. doi: 10.1051/medsci/20173305010.

Baranek T, Morello E, Valayer A, Aimar RF, Bréa D, Henry C, Besnard AG, Dalloneau E, Guillon A, Dequin PF, Narni-Mancinelli E, Vivier E, Laurent F, Wei Y, Paget C, Si-Tahar M. FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection. Front Immunol. 2017 Feb 13;8:123. doi: 10.3389/fimmu.2017.00123

Valayer A, Brea D, Lajoie L, Avezard L, Combes-Soia L, Labas V, Korkmaz B, Thibault G, Baranek T, Si-Tahar M. Neutrophils can disarm NK cell response through cleavage of NKp46. J Leukoc Biol. 2017 Jan;101(1):253-259. doi: 10.1189/jlb.3AB0316-140RR. Epub 2016 Sep 1.