cepr.team1.admin

The CEPR is decked out in pink in support of #OctobreRose

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« Pink October » celebrates its 31st anniversary in 2024. The event, symbolized by the pink ribbon, focuses on organized screening, in conjunction with the French National Cancer Institute. The slogan of the information and awareness campaign running throughout October is: « Stronger together! The aim of Pink October is to raise awareness and encourage breast cancer screening, with a view to reducing the number of deaths caused by this cancer.  

A Grand Prize in France2030 iPhD national competition for CEPR!

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CEPR Team 1’s SAChA project wins Grand Prize in France2030 iPhD national competition! Adeline Cezard, former PhD student and current young postdoctoral researcher with Team 1 CEPR, has won one of the Grand Prizes in the France2030 iPhD national competition! 🏆 This distinction highlights her contribution to the SAChA project, an innovative program dedicated to the development of antiviral therapies, co-funded by C-VaLo and the CATRIEM consortium.

4-year ANR funding obtained (PROJECT COORDINATION: M. Si-Tahar): Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections – (SuccesS)

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The emergence of pandemic respiratory viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV). There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed. Vaccination should constitute the most preventive strategy. However, the intrinsic antigenic drift of IAV impairs vaccine protection. Besides, previous coronaviruses crises showed that poorly neutralizing antibodies developed after vaccination may enhance subsequent infection. Current vaccine hesitancy also remains a barrier to full population inoculation against SARS-CoV-2. Our ANR project is thus aimed to develop an innovative metabolic therapy against those two viruses, delivered via the pulmonary route, based on (i) recent evidence that metabolites are key effectors of the host antimicrobial response and (ii) our preliminary data which identified two metabolites with anti-IAV and anti-SARS-CoV-2 antiviral activity. source : https://anr.fr/Projet-ANR-21-CE18-0061

Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein »

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Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jérôme Bourgeais, Frédéric Picou, Virginie Vasseur, Léa Meyer, Christophe Chevalier, Adrien Auvet, José M Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amélie Donchet, Thibaut Crépin, Pieter S Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Mustapha Si-Tahar, […] source : https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15229