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Congratulations to Thomas Secher on obtaining his HDR

Thesis / Par

Congratulations to Thomas, who brilliantly obtained his habilitation to direct research ! This is a remarkable accomplishment that reflects his  dedication and expertise in the field of therapeutic antibodies for the treatment of respiratory diseases. Wishing him every success in his academic journey !

Congratulation to Emilie Barsac for her thesis defense

Thesis / Par

Congratulations to Emilie Barsarc for the successful defense of her thesis, « Study of MAIT cell impact during pneumococcal-mediated pneumonia« .   Her work allows a better characterization of transactivation mechanisms linked to the protective functions of MAIT cells, offering valuable insights into immune responses against pneumococcal infections. 

Characterization of anatomical variations of the nasal cavity in a subset of European patients and their impact on intranasal drug delivery

Laisser un commentaire / Publication / Par

Mike Pasteur, Guillaume Arsouze, Guy Ilango, Déborah Le Pennec ,Dimitri Kulker, Anaïs Heyraud, Jean-Philippe Cottier, Charles Aussedat, Nathalie Heuzé-Vourc’h, Virginie Hervé, Sandrine Le Guellec Anatomical 3D-printed nasal casts are valuable models to investigate intranasal drug deposition, providing preclinical data that cannot be obtained in animal models. However, these models are limited since they are often derived from a single patient or represent a mean of several groups.  The present study aimed to better characterize the anatomical differences of the nasal cavity in a European sub-population and to assess the potential impact of anatomical variations on intranasal deposition by medical devices. Ninety-eight cranial computed tomography scans of patients were selected and analyzed in 2D and 3D conformations.  They showed symmetry of cavities and a high level of heterogeneity of measurements, especially volume and area, in the population. Three anatomical groups with distinct nasal geometry were identified and 3D nasal casts of the most representative patient of each group were printed.  Fluorescein was administered using three medical devices: a nasal spray, a sonic jet nebulizer and a prototype mesh-nebulizer. The deposition profiles were compared with the Aeronose® as a reference. Our results show that anatomical variations influenced the deposition profiles depending on the device, with a higher variation with spray and the mesh-nebulizer.  This work emphasises the importance of anatomical parameters on drug intranasal deposition and the need to evaluate inhaled drugs on different 3D nasal casts reflecting the target population. Full text available on :  ScienceDirect

Learn more about Advances in Respiratory Pathologies

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For the « Fête de la Science », come and visit our stand in the « Village des Sciences ». For the Fête de la Science on October 12 and 13, 2024, we invite you to visit our stand at the « Village des Sciences » 2024. Come and explore the research carried out by our four teams, who are joining forces to better understand the cellular and molecular mechanisms of inflammatory and infectious phenomena within our lungs, in order to propose new therapeutic strategies. Don’t miss this unique opportunity to delve into the heart of scientific research and see how our Center strives to push back the boundaries of knowledge to improve respiratory health. We look forward to seeing you at our stand to share our passion for science and innovation!   URL : https://www.fetedelascience.fr/decouvrez-les-avancees-en-pathologies-respiratoires

Researcher for an hour : an animated tour of Our laboratory.

Event / Par

Come and discover the world of research and learn more about respiratory diseases! In the age of multidisciplinary knowledge, the concept of “Ocean of Knowledge” takes on its full meaning in medical research. Within this universe, the 4 teams at the Research Center for Respiratory Diseases are experimenting, analyzing and working in synergy to better understand the cellular and molecular mechanisms involved in these inflammatory and infectious phenomena, in order to navigate towards new therapeutic frontiers. As part of the Fête de la Science, the Research Center for Respiratory Diseases will be opening its doors to you on October 8, 2024, for a one-hour visit during which all 4 teams will be delighted to show you around their research activities and exchange ideas with you, through themed workshops. Register by telephone on 02 47 36 60 49 or by e-mail at secretariat.cepr@univ-tours.fr to choose the time slot that suits you best! Meet at 10 boulevard Tonnellé in Tours at the time of your reservation, in front of the Faculty of Medicine.   URL : https://www.fetedelascience.fr/chercheur-pour-une-heure